A New Pathogenesis of Albuminuria: Role of Transcytosis

A New Pathogenesis of Albuminuria: Role of Transcytosis

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Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis.In kidney, macromolecular components in the serum, such as albumin, low-density lipoprotein and bushranger awning immunoglobulins, pass through the glomerular filtration barrier (GFB) and proximal tubular cells (PTCs) by transcytosis.Protein transcytosis plays a vital role in the pathology of albuminuria, which causes progressive destruction of the GFB structure and function.However, the pathophysiological consequences of protein transcytosis in the kidney remain largely unknown.

This article summarizes 2000 bmw 528i front bumper recent researches on the regulation of albumin transcytosis across the GFB and PTCs in both physiological and pathological conditions.Understanding the mechanism of albumin transcytosis may reveal potential therapeutic targets for prevention or alleviation of the pathological consequences of albuminuria.